Workshop on POPULATION OPTIMUM DESIGN OF EXPERIMENTS PODE 2015 BOOK OF ABSTRACTS
نویسندگان
چکیده
In this work we apply the FDA proposed precision criteria necessary for pediatric pharmacokinetic studies (Wang et. al., 2012) as a stopping criteria for a model based adaptive optimal design (MBAOD) of an adult to children pharmacokinetic bridging study. We demonstrate the power of the MBAOD compared to both traditional designs as well as non-adaptive optimal designs.
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